The Quantum CoPilot User-Friendly Wireless TTL Flash Controller for Canon is capable of controlling three independent groups of remote Qflashes in manual, automatic or TTL modes. There is a QF91C for Canon E-TTL. The Quantum CoPilot prioritizes user-friendliness by eschewing complex LCD menus for old-school analogue dials. The result is a compact transmitter that slides into your camera hot-shoe. By twiddling each of its three knobs you can intuitively adjust the power level (or exposure compensation) of your off-camera flashes. At the flick of a switch you can quickly swap between M and TTL modes. The interface is similar in some respects to the Pocket Wizard AC3 ZoneController.
The Quantum CoPilot has an LED autofocus-assist lamp, sending out an infrared beam to help autofocussing in low-light situations.
The CoPilot is primarily for commanding Quantum's radio-enabled Qflash units such as the Trio and T5dR. However, you can incorporate older Qflashes and non-Quantum speedlights into your setup using FreeXWire FW8R or FW10W radio receivers. By adding a QLink adapter you'll get full TTL control of a Canon Speedlite from up to 100 m away.
Though there is no hot-shoe on top of the transmitter, you can connect a "local" Qflash (presumably mounted on a bracket, or handheld) via cable with TTL pass-through. This connects to a socket in the side of the CoPilot transmitter. There's also a Mini-USB socket for future firmware updates. Unfortunately the CoPilot's control panel isn't made up of LEDs or backlit, so it might be a challenge reading your settings in the dark. Other potential annoyances include non-standard CR123A batteries and a plastic (vs. metal) hot-shoe foot.